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Blood and Marrow Transplantation | Blood & Marrow Transplantation & Cellular Therapy Division | Stanford MedicineStanford Medicine Blood & Marrow Transplantation & Cellular Therapy Division Site Nav Menu BMT & Cell Therapy Stanford Medicine Explore Stanford Medicine Health Care Find a doctor Adult-care doctor Pediatrician or pediatric specialist Obstetrician Clinics & Services Adult care Pediatric care Obstetrics Clinical trials Locations Stanford Health Care Stanford Children’s Health Emergency Department Dial 911 in the event of a medical emergency Explore Health Care Learn how we are healing patients through science & compassion Back Research Basic science departments Clinical science departments Institutes Research centers See full directory Research Resources Research administration Academic profiles Clinical trials Funding opportunities See all Professional Training Postdoctoral scholars Clinical research fellows Research News ‘Smart speaker’ shows potential for better self-management of Type 2 diabetes Explore Research Learn how we are fueling innovation Back Education MD program PA Programs PhD programs Masters programs Continuing Medical Education Postdoctoral scholars Residencies & fellowships High School & Undergraduate Programs See all Education Resources Academic profiles School Administration Basic science departments Clinical science departments Alumni services Faculty resources Diversity programs Lane Library Student resources Education News Students from far and near begin medical studies at Stanford Explore Education Learn how we empower tomorrow’s leaders Back Give Support Stanford Medicine Support teaching, research, and patient care. 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We are a nationally recognized center of excellence, fully accredited by the Foundation for the Accreditation of Cellular Therapy (FACT) and a proud member of the Blood and Marrow Transplant Clinical Trials Network of the National Cancer Institute. Read More Listen to the latest podcast of The Bloodline with LLS Stanford Medicine’s Lori Muffly, MD and Matthew Frank, MD, PhD from Stanford Medicine in Stanford, CA, were recently featured on The Bloodline with LLS, the podcast by The Leukemia & Lymphoma Society (LLS) for patients and caregivers. In this episode, the doctors delve into what Minimal/Measurable Disease (MRD) is, which blood cancers testing is currently used on, and how we can utilize it to more accurately monitor patients and customize treatment. The doctors also share exciting possibilities on how MRD and other testing can benefit patients in the future. CAR T cells with dual targeting of CD19 and CD22 in adult patients with recurrent or refractory B cell malignancies: a phase 1 trial Learn more about our highly innovative clinical trials for leukemia and MDS: BMT 372. Phase 1 reduced intensity BMT 377. Phase 3 full intensity BMT 378. Phase 1 full intensity with CAR-TThe BMT-CT program at Stanford performs autologous and allogeneic transplantations for over 450 patients each year. The program has been very successful with a history of limited morbidity rates and acute mortality that is well below most published reports. Read more Presentations by Stanford BMT-CT ASH Annual Meeting, December 2023 Tandem Meetings, February 2024 BMT Fellowship Since 2007, the program has trained more than 45 physicians with majority of our graduates now working in the field of transplantation and cellular therapy throughout the country. Read more Division Events Recent stories Two is Better Than One: Arming the T-Cells with Dual Cancer-Targeting Antibodies One way to bring the powerful cellular immunity and antibody directed targeting together is to construct the chimeric antigen receptor (CAR) T-cells. In this strategy, the patient’s own T-cells are genetically engineered to produce a hybrid molecule (the CAR) on these killing cells. Precision Medicine: New Technology That Changes the Clinical Practice In order to monitor disease after a curative treatment such as allogeneic transplant, pioneer works from Drs. David Miklos and Wen-Kai Weng have established the utility of high-throughput sequencing (HTS) of either B-cell receptor (BCR) or T-cell receptor (TCR) in monitoring minimal residual disease (MRD). Teaching a young dog new tricks: Story of a kinase and its inhibitor The development of normal lymphocytes is a well-orchestrated process, that begins in the bone marrow. This process involves a functional antigen receptor (B-cell receptor or T-cell receptor) and a dozen of intermediators, including adaptor proteins and kinases that form a network of signaling pathways inside the cells. The many challenges to success Since the establishment of Stanford BMT program in 1987, many aspects of the clinical practice have changed. Clinical Story: It Takes a World to Cure a Cancer When Robin was first diagnosed with acute myeloid leukemia in December 2011, she knew that it would be a long journey for her fight against this cancer. Translational Research: Cellular Therapeutics While the graft-versus-tumor effect provided by the donor graft can be very powerful in controlling the disease, disease relapse is still the primary reason that patients do not do well after an allogeneic transplantation. Bench to Bedside: Disruptive Innovation While allogeneic transplantation can be life saving for patients with hematologic malignancies, or inherited disorders such as several forms of immuno-deficiency, the transplant-related side effects and complications remain the biggest hurdles. The...